Ontology highlight
ABSTRACT:
SUBMITTER: Bao L
PROVIDER: S-EPMC5983317 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Bao Li L Qian Zhaoyang Z Lyng Maria B MB Wang Ling L Yu Yuan Y Wang Ting T Zhang Xiuqing X Yang Huanming H Brünner Nils N Wang Jun J Ditzel Henrik J HJ
The Journal of clinical investigation 20180423 6
Single cancer cell-sequencing studies currently use randomly selected cells, limiting correlations among genomic aberrations, morphology, and spatial localization. We laser-captured microdissected single cells from morphologically distinct areas of primary breast cancer and corresponding lymph node metastasis and performed whole-exome or deep-target sequencing of more than 100 such cells. Two major subclones coexisted in different areas of the primary tumor, and the lymph node metastasis origina ...[more]