Ontology highlight
ABSTRACT:
SUBMITTER: Li XY
PROVIDER: S-EPMC5983325 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Li Xian-Yang XY Das Indrajit I Lepletier Ailin A Addala Venkateswar V Bald Tobias T Stannard Kimberley K Barkauskas Deborah D Liu Jing J Aguilera Amelia Roman AR Takeda Kazuyoshi K Braun Matthias M Nakamura Kyohei K Jacquelin Sebastien S Lane Steven W SW Teng Michele Wl MW Dougall William C WC Smyth Mark J MJ
The Journal of clinical investigation 20180514 6
Critical immune-suppressive pathways beyond programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) require greater attention. Nectins and nectin-like molecules might be promising targets for immunotherapy, since they play critical roles in cell proliferation and migration and exert immunomodulatory functions in pathophysiological conditions. Here, we show CD155 expression in both malignant cells and tumor-infiltrating myeloid cells in humans and mice. Cd155-/- mice displayed reduced tum ...[more]