FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.
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ABSTRACT:
SUBMITTER: Penke LR
PROVIDER: S-EPMC5983327 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.
Penke Loka R LR Speth Jennifer M JM Dommeti Vijaya L VL White Eric S ES Bergin Ingrid L IL Peters-Golden Marc M
The Journal of clinical investigation 20180507 6
While the transcription factor forkhead box M1 (FOXM1) is well known as a proto-oncogene, its potential role in lung fibroblast activation has never been explored. Here, we show that FOXM1 is more highly expressed in fibrotic than in normal lung fibroblasts in humans and mice. FOXM1 was required not only for cell proliferation in response to mitogens, but also for myofibroblast differentiation and apoptosis resistance elicited by TGF-β. The lipid mediator PGE2, acting via cAMP signaling, was ide ...[more]
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