Ontology highlight
ABSTRACT:
SUBMITTER: Maurer AC
PROVIDER: S-EPMC5983388 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Maurer Anna C AC Pacouret Simon S Cepeda Diaz Ana Karla AK Blake Jessica J Andres-Mateos Eva E Vandenberghe Luk H LH
Cell reports 20180501 6
The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes relevant to gene therapy, including vector production and host tropism. Fundamental to these aspects is the mechanism of AAV capsid assembly. Here, the role of the viral co-factor assembly-activating protein (AAP) was evaluated in 12 naturally occurring AAVs and 9 putative ancestral capsid intermediates. The result ...[more]