In silico approaches for predicting the half-life of natural and modified peptides in blood.
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ABSTRACT:
SUBMITTER: Mathur D
PROVIDER: S-EPMC5983457 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
In silico approaches for predicting the half-life of natural and modified peptides in blood.
Mathur Deepika D Singh Sandeep S Mehta Ayesha A Agrawal Piyush P Raghava Gajendra P S GPS
PloS one 20180601 6
This paper describes a web server developed for designing therapeutic peptides with desired half-life in blood. In this study, we used 163 natural and 98 modified peptides whose half-life has been determined experimentally in mammalian blood, for developing in silico models. Firstly, models have been developed on 261 peptides containing natural and modified residues, using different chemical descriptors. The best model using 43 PaDEL descriptors got a maximum correlation of 0.692 between the pre ...[more]
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