Ontology highlight
ABSTRACT:
SUBMITTER: Chien Y
PROVIDER: S-EPMC5983630 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chien Yueh Y Chou Shih-Jie SJ Chang Yuh-Lih YL Leu Hsin-Bang HB Yang Yi-Ping YP Tsai Ping-Hsing PH Lai Ying-Hsiu YH Chen Kuan-Hsuan KH Chang Wei-Chao WC Sung Shih-Hsien SH Yu Wen-Chung WC
International journal of molecular sciences 20180516 5
(1) Background: A high incidence of intervening sequence (IVS)4+919 G>A mutation with later-onset cardiac phenotype have been reported in a majority of Taiwan Fabry cohorts. Some evidence indicated that conventional biomarkers failed to predict the long-term progression and therapeutic outcome; (2) Methods: In this study, we constructed an induced pluripotent stem cell (iPSC)-based platform from Fabry cardiomyopathy (FC) patients carrying IVS4+919 G>A mutation to screen for potential targets tha ...[more]