Ontology highlight
ABSTRACT:
SUBMITTER: Amin N
PROVIDER: S-EPMC5984098 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Amin N N de Vrij F M S FMS Baghdadi M M Brouwer R W W RWW van Rooij J G J JGJ Jovanova O O Uitterlinden A G AG Hofman A A Janssen H L A HLA Darwish Murad S S Kraaij R R Stedehouder J J van den Hout M C G N MCGN Kros J M JM van IJcken W F J WFJ Tiemeier H H Kushner S A SA van Duijn C M CM
Molecular psychiatry 20170321 5
Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly facilitate the elucidation of the biological mechanisms underlying depression, however, its complex etiology has proved to be a major bottleneck in the identification of its genetic risk factors, especially in genome-wide association-like studies. In this study, we exploit the properties of a genetic isolate and its family-based structure t ...[more]