Effect of Grafting on Aggregation of Intrinsically Disordered Proteins.
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ABSTRACT:
SUBMITTER: Osmanovic D
PROVIDER: S-EPMC5985032 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Effect of Grafting on Aggregation of Intrinsically Disordered Proteins.
Osmanovic Dino D Rabin Yitzhak Y
Biophysical journal 20180131 3
A significant part of the proteome is composed of intrinsically disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work, we consider IDPs that have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers, and use computer simulations to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect t ...[more]
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