Ontology highlight
ABSTRACT:
SUBMITTER: Greene NP
PROVIDER: S-EPMC5985334 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Greene Nicholas P NP Kaplan Elise E Crow Allister A Koronakis Vassilis V
Frontiers in microbiology 20180528
The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative bacteria. Here, we review recent structural and functional data on MacB and its homologs. MacB has a fold that is distinct from other structurally characterized ABC transporters and uses a unique molecular mechanism termed mechanotransmission. Unlike other bacterial ABC transporters, MacB does not transport su ...[more]