Ontology highlight
ABSTRACT:
SUBMITTER: Sheng Y
PROVIDER: S-EPMC5985372 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in immunology 20180528
Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine <i>via</i> its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including regulatory T cells and myeloid-derived suppressor cells. In contrast to TNFR1, TNFR2 diverts the tumor-inhibiting TNF into a tumor-advocating factor. TNFR2 directly promotes the proliferation of some kinds of tumor cells. Also activating immunos ...[more]