Dataset Information

Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships.

ABSTRACT:

Background

Cytochrome P450s form an important group of enzymes involved in xenobiotics degradation and metabolism, both primary and secondary. These enzymes are also useful in industry as biotechnological tools for bioconversion and a few are reported to be involved in pathogenicity. Trichoderma spp. are widely used in industry and agriculture and are known for their biosynthetic potential of a large number of secondary metabolites. For realising the full biosynthetic potential of an organism, it is important to do a genome-wide annotation and cataloguing of these enzymes.

Results

Here, we have studied the genomes of seven species (T. asperellum, T. atroviride, T. citrinoviride, T. longibrachiatum, T. reesei , T. harzianum and T. virens) and identified a total of 477 cytochrome P450s. We present here the classification, evolution and structure as well as predicted function of these proteins. This study would pave the way for functional characterization of these groups of enzymes and will also help in realization of their full economic potential.

Conclusion

Our CYPome annotation and evolutionary studies of the seven Trichoderma species now provides opportunities for exploration of research-driven strategies to select Trichoderma species for various applications especially in relation to secondary metabolism and degradation of environmental pollutants.

SUBMITTER: Chadha S

PROVIDER: S-EPMC5985579 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genome-wide analysis of cytochrome P450s of <i>Trichoderma</i> spp.: annotation and evolutionary relationships.

Chadha Sonia S Mehetre Sayaji T ST Bansal Ravindra R Kuo Alan A Aerts Andrea A Grigoriev Igor V IV Druzhinina Irina S IS Mukherjee Prasun K PK

Fungal biology and biotechnology 20180604

<h4>Background</h4>Cytochrome P450s form an important group of enzymes involved in xenobiotics degradation and metabolism, both primary and secondary. These enzymes are also useful in industry as biotechnological tools for bioconversion and a few are reported to be involved in pathogenicity. <i>Trichoderma</i> spp. are widely used in industry and agriculture and are known for their biosynthetic potential of a large number of secondary metabolites. For realising the full biosynthetic potential of ...[more]

PMID: 29881631

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