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Genome-wide association analyses identify new loci influencing intraocular pressure.

ABSTRACT: Elevated intraocular pressure (IOP) is a significant risk factor for glaucoma, the leading cause of irreversible blindness worldwide. While previous studies have identified numerous genetic variants associated with IOP, these loci only explain a fraction of IOP heritability. Recently established of biobank repositories have resulted in large amounts of data, enabling the identification of the remaining heritability for complex traits. Here, we describe the largest genome-wide association study of IOP to date using participants of European ancestry from the UK Biobank. We identified 671 directly genotyped variants that are significantly associated with IOP (P?

SUBMITTER: Gao XR

PROVIDER: S-EPMC5985721 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Genome-wide association analyses identify new loci influencing intraocular pressure.

Gao X Raymond XR Huang Hua H Nannini Drew R DR Fan Fangda F Kim Heejin H

Human molecular genetics 20180601 12

Elevated intraocular pressure (IOP) is a significant risk factor for glaucoma, the leading cause of irreversible blindness worldwide. While previous studies have identified numerous genetic variants associated with IOP, these loci only explain a fraction of IOP heritability. Recently established of biobank repositories have resulted in large amounts of data, enabling the identification of the remaining heritability for complex traits. Here, we describe the largest genome-wide association study o ...[more]

PMID: 29617998

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