Ontology highlight
ABSTRACT:
SUBMITTER: Dunning J
PROVIDER: S-EPMC5985949 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Dunning Jake J Blankley Simon S Hoang Long T LT Cox Mike M Graham Christine M CM James Philip L PL Bloom Chloe I CI Chaussabel Damien D Banchereau Jacques J Brett Stephen J SJ Moffatt Miriam F MF O'Garra Anne A Openshaw Peter J M PJM
Nature immunology 20180518 6
Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures reflective of interferon-related antiviral pathways were common up to day 4 of symptoms in patients wh ...[more]