Ontology highlight
ABSTRACT:
SUBMITTER: Isogai Y
PROVIDER: S-EPMC5986056 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Isogai Yasuhiro Y Takao Eisuke E Nakamura Ryuta R Kato Minoru M Kawabata Shigeki S
FEBS open bio 20180511 6
Proteins are attractive materials for supramolecular chemistry due to their multifunctionality and self-organization ability. In this work, we synthesized a diheme compound, in which two iron-protoporphyrin IX molecules are associated via a linker chain, and introduced it into a <i>de novo</i> designed four-helix bundle protein with two heme-binding sites. The protein gradually bound the diheme compound by <i>bis</i>-histidyl ligation and formed supramolecular polymers. Polymer formation was obs ...[more]