Ontology highlight
ABSTRACT:
SUBMITTER: Hu MY
PROVIDER: S-EPMC5986267 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hu Marian Y MY Yan Jia-Jiun JJ Petersen Inga I Himmerkus Nina N Bleich Markus M Stumpp Meike M
eLife 20180501
Efficient pH regulation is a fundamental requisite of all calcifying systems in animals and plants but with the underlying pH regulatory mechanisms remaining largely unknown. Using the sea urchin larva, this work identified the SLC4 HCO<sub>3</sub><sup>-</sup> transporter family member <i>SpSlc4a10</i> to be critically involved in the formation of an elaborate calcitic endoskeleton. <i>SpSlc4a10</i> is specifically expressed by calcifying primary mesenchyme cells with peak expression during de n ...[more]