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The distinct structural preferences of tau protein repeat domains.

ABSTRACT: The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.

SUBMITTER: Li X 

PROVIDER: S-EPMC5986281 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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The distinct structural preferences of tau protein repeat domains.

Li Xuhua X   Dong Xuewei X   Wei Guanghong G   Margittai Martin M   Nussinov Ruth R   Ma Buyong B  

Chemical communications (Cambridge, England) 20180501 45

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats. ...[more]

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