Ontology highlight
ABSTRACT:
SUBMITTER: Lau UY
PROVIDER: S-EPMC5986558 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lau Uland Y UY Pelegri-O'Day Emma M EM Maynard Heather D HD
Macromolecular rapid communications 20171218 5
There is a significant need for new biodegradable protein stabilizing polymers. Herein, the synthesis of a polymer with trehalose side chains and hydrolytically degradable backbone esters and its evaluation for protein stabilization and cytotoxicity are described. Specifically, an alkene-containing parent polymer is synthesized by reversible addition-fragmentation chain transfer polymerization, and thiolated trehalose is installed using a radical-initiated thiol-ene reaction. The stabilizing pro ...[more]