Ontology highlight
ABSTRACT:
SUBMITTER: Martin AR
PROVIDER: S-EPMC5986696 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Martin Alicia R AR Karczewski Konrad J KJ Kerminen Sini S Kurki Mitja I MI Sarin Antti-Pekka AP Artomov Mykyta M Eriksson Johan G JG Esko Tõnu T Genovese Giulio G Havulinna Aki S AS Kaprio Jaakko J Konradi Alexandra A Korányi László L Kostareva Anna A Männikkö Minna M Metspalu Andres A Perola Markus M Prasad Rashmi B RB Raitakari Olli O Rotar Oxana O Salomaa Veikko V Groop Leif L Palotie Aarno A Neale Benjamin M BM Ripatti Samuli S Pirinen Matti M Daly Mark J MJ
American journal of human genetics 20180426 5
Finland provides unique opportunities to investigate population and medical genomics because of its adoption of unified national electronic health records, detailed historical and birth records, and serial population bottlenecks. We assembled a comprehensive view of recent population history (≤100 generations), the timespan during which most rare-disease-causing alleles arose, by comparing pairwise haplotype sharing from 43,254 Finns to that of 16,060 Swedes, Estonians, Russians, and Hungarians ...[more]