Ontology highlight
ABSTRACT:
SUBMITTER: Han K
PROVIDER: S-EPMC5986741 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20180604 1
The mechanisms underlying luteolin-induced inhibition of prostate cancer (PCa) stemness have remained elusive. Here, we report that luteolin suppresses PCa stemness through Wnt signaling by upregulation of FZD6 (frizzled class receptor 6). Luteolin inhibits PCa cell proliferation, migration, self-renewal as well as the expression of prostate cancer stem cell markers in vitro. Through iTRAQ-based quantitative proteomics study, we identified 208 differentially expressed proteins in luteolin-treate ...[more]