Ontology highlight
ABSTRACT:
SUBMITTER: Funck-Brentano T
PROVIDER: S-EPMC5987170 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
The Journal of endocrinology 20180502 1
WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health are unknown, we determined their effects on bone mass and strength. Twelve-week-old C57BL/6N female mice were treated by the Porcupine inhibitors LGK974 (low dose = 3 mg/kg/day; high dose = 6 mg/kg/day) ...[more]