Dataset Information

Carbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS).

ABSTRACT:

Background

Carbapenem resistance in Klebsiella pneumoniae is of significant public health concern and recently spread across several countries. We investigated the extent of carbapenem non-susceptibility in K. pneumoniae isolates in Germany.

Methods

We analysed 2011-2016 data from the German Antimicrobial Resistance Surveillance (ARS) System, which contains routine data of antimicrobial susceptibility testing from voluntarily participating German laboratories. Klebsiella pneumoniae isolates tested resistant or intermediate against an antibiotic were classified as non-susceptible.

Results

We included 154,734 isolates from 655 hospitals in the analysis. Carbapenem non-susceptibility in K. pneumoniae isolates was low in Germany 0.63% (95% CI 0.51-0.76%). However, in continuously participating hospitals the number of K. pneumoniae isolates almost doubled and we found evidence for a slowly increasing trend for non-susceptibility (OR?=?1.20 per year, 95% CI 1.09-1.33, p?ConclusionCarbapenem non-susceptibility in K. pneumoniae isolates in Germany is still low. However, it is slowly increasing and in the light of the strong increase of K. pneumoniae isolates over the last year this poses a significant challenge to public health. Continued surveillance to closely monitor trends as well as infection control and antibiotic stewardship activities are necessary to preserve treatment options.

SUBMITTER: Koppe U

PROVIDER: S-EPMC5987571 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Carbapenem non-susceptibility of <i>Klebsiella pneumoniae</i> isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS).

Koppe Uwe U von Laer Anja A Kroll Lars E LE Noll Ines I Feig Marcel M Schneider Marc M Claus Hermann H Eckmanns Tim T Abu Sin Muna M

Antimicrobial resistance and infection control 20180605

<h4>Background</h4>Carbapenem resistance in <i>Klebsiella pneumoniae</i> is of significant public health concern and recently spread across several countries. We investigated the extent of carbapenem non-susceptibility in <i>K. pneumoniae</i> isolates in Germany.<h4>Methods</h4>We analysed 2011-2016 data from the German Antimicrobial Resistance Surveillance (ARS) System, which contains routine data of antimicrobial susceptibility testing from voluntarily participating German laboratories. <i>Kle ...[more]

PMID: 29992016

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