Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

ABSTRACT: T follicular regulatory (Tfr) cells are a population of CD4⁺ T cells that express regulatory T cell markers and have been shown to suppress humoral immunity. However, the precise mechanisms and location of Tfr-mediated suppression in the lymph node (LN) microenvironment are unknown. Using highly multiplexed quantitative imaging and functional assays, we examined the spatial distribution, suppressive function, and preferred interacting partners of Tfr cells in human mesenteric LNs. We find that the majority of Tfr cells express low levels of PD-1 and reside at the border between the T cell zone and B cell follicle, with very few found in the germinal centers (GCs). Although PD-1⁺ Tfr cells expressed higher levels of CD38, CTLA-4, and GARP than PD-1^Neg Tfr ce

SUBMITTER: Sayin I 

PROVIDER: S-EPMC5987920 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature