Multi-omics "upstream analysis" of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer.
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ABSTRACT:
SUBMITTER: Kel AE
PROVIDER: S-EPMC5988513 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Multi-omics "upstream analysis" of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer.
Kel Alexander E AE Stegmaier Philip P Valeev Tagir T Koschmann Jeannette J Poroikov Vladimir V Kel-Margoulis Olga V OV Wingender Edgar E
EuPA open proteomics 20160909
We present an "upstream analysis" strategy for causal analysis of multiple "-omics" data. It analyzes promoters using the TRANSFAC database, combines it with an analysis of the upstream signal transduction pathways and identifies master regulators as potential drug targets for a pathological process. We applied this approach to a complex multi-omics data set that contains transcriptomics, proteomics and epigenomics data. We identified the following potential drug targets against induced resistan ...[more]
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