Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages.
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ABSTRACT:
SUBMITTER: Duhamel M
PROVIDER: S-EPMC5988551 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages.
Duhamel Marie M Rodet Franck F Murgoci Adriana A Wisztorski Maxence M Day Robert R Fournier Isabelle I Salzet Michel M
EuPA open proteomics 20160305
We demonstrated here thanks to proteomic, that proprotein convertase 1/3 knockdown macrophages present all the characteristic of activated pro-inflammatory macrophages. TLR4 and TLR9 signaling pathways can be enhanced leading to the secretion of pro-inflammatory factors and antitumor factors. We can control their activation by controlling one enzyme, PC1/3. In a tumor context, PC1/3 inhibition in macrophages may reactivate them and lead to a cytokine storm after stimulation "at distance" with a ...[more]
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