Ontology highlight
ABSTRACT:
SUBMITTER: Addison M
PROVIDER: S-EPMC5988564 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Addison Megan M Xu Qiling Q Cayuso Jordi J Wilkinson David G DG
Developmental cell 20180503 5
The patterning of tissues to form subdivisions with distinct and homogeneous regional identity is potentially disrupted by cell intermingling. Transplantation studies suggest that homogeneous segmental identity in the hindbrain is maintained by identity switching of cells that intermingle into another segment. We show that switching occurs during normal development and is mediated by feedback between segment identity and the retinoic acid degrading enzymes, cyp26b1 and cyp26c1. egr2, which speci ...[more]