Ontology highlight
ABSTRACT:
SUBMITTER: Corbett AH
PROVIDER: S-EPMC5988930 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Current opinion in cell biology 20180306
A large number of mutations in genes that encode RNA binding proteins cause human disease. Many of these RNA binding proteins mediate key steps in post-transcriptional regulation of gene expression from mRNA processing to eventual decay in the cytoplasm. Surprisingly, these RNA binding proteins, which are ubiquitously expressed and play fundamental roles in gene expression, are often altered in tissue-specific disease. Mutations linked to disease impact nearly every post-transcriptional processi ...[more]