Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline.
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ABSTRACT:
SUBMITTER: Sampedro F
PROVIDER: S-EPMC5989044 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Early Gray Matter Volume Loss in MAPT H1H1 <i>de Novo</i> PD Patients: A Possible Association With Cognitive Decline.
Sampedro Frederic F Marín-Lahoz Juan J Martínez-Horta Saul S Pagonabarraga Javier J Kulisevsky Jaime J
Frontiers in neurology 20180530
The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 <i>de novo</i> PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic pro ...[more]
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