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Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle.

ABSTRACT: An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex.

SUBMITTER: Tseng TS

PROVIDER: S-EPMC5989323 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle.

Tseng Ta-Sheng Andrew TS Burstyn Judith N JN

Chemical communications (Cambridge, England) 20081027 46

An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex. ...[more]

PMID: 19082122

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