Ontology highlight
ABSTRACT:
SUBMITTER: Wilder-Smith A
PROVIDER: S-EPMC5989336 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Wilder-Smith Annelies A Vannice Kirsten K Durbin Anna A Hombach Joachim J Thomas Stephen J SJ Thevarjan Irani I Simmons Cameron P CP
BMC medicine 20180606 1
<h4>Background</h4>Various Zika virus (ZIKV) vaccine candidates are currently in development. Nevertheless, unique challenges in clinical development and regulatory pathways may hinder the licensure of high-quality, safe, and effective ZIKV vaccines.<h4>Discussion</h4>Implementing phase 3 efficacy trials will be difficult given the challenges of the spatio-temporal heterogeneity of ZIKV transmission, the unpredictability of ZIKV epidemics, the broad spectrum of clinical manifestations making a s ...[more]