Ontology highlight
ABSTRACT:
SUBMITTER: Akhtar AA
PROVIDER: S-EPMC5989694 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Stem cell reports 20180426 6
Trophic factor delivery to the brain using stem cell-derived neural progenitors is a powerful way to bypass the blood-brain barrier. Protection of diseased neurons using this technology is a promising therapy for neurodegenerative diseases. Glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is being used in a clinical trial for amyotrophic lateral sclerosis. However, chronic trophic factor delivery prohibits dose adjustment or cessation if side ...[more]