Ontology highlight
ABSTRACT:
SUBMITTER: Riddle MR
PROVIDER: S-EPMC5989729 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Riddle Misty R MR Aspiras Ariel C AC Gaudenz Karin K Peuß Robert R Sung Jenny Y JY Martineau Brian B Peavey Megan M Box Andrew C AC Tabin Julius A JA McGaugh Suzanne S Borowsky Richard R Tabin Clifford J CJ Rohner Nicolas N
Nature 20180321 7698
Periodic food shortages are a major challenge faced by organisms in natural habitats. Cave-dwelling animals must withstand long periods of nutrient deprivation, as-in the absence of photosynthesis-caves depend on external energy sources such as seasonal floods. Here we show that cave-adapted populations of the Mexican tetra, Astyanax mexicanus, have dysregulated blood glucose homeostasis and are insulin-resistant compared to river-adapted populations. We found that multiple cave populations carr ...[more]