Ontology highlight
ABSTRACT:
SUBMITTER: Idichi T
PROVIDER: S-EPMC5989856 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Idichi Tetsuya T Seki Naohiko N Kurahara Hiroshi H Fukuhisa Haruhi H Toda Hiroko H Shimonosono Masataka M Okato Atsushi A Arai Takayuki T Kita Yoshiaki Y Mataki Yuko Y Kijima Yuko Y Maemura Kosei K Natsugoe Shoji S
Cancer science 20180522 6
We previously used RNA sequencing to establish the microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC). We found that both strands of pre-miR-148a (miR-148a-5p: the passenger strand and miR-148a-3p: the guide strand) were downregulated in cancer tissues. Ectopic expression of miR-148a-5p and miR-148a-3p significantly inhibited cancer cell migration and invasion, indicating that both strands of pre-miR-148a had tumor-suppressive roles in PDAC cells. In silico database ...[more]