Dataset Information

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

ABSTRACT: Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between sexes. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts, and legumes) and bone loss at the femoral neck, trochanter, and lumbar spine (L2 to L4 ) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed using the Willett food-frequency questionnaire, and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Follow-up BMD was measured in 2001-2005 and 2005-2008 among 792 men (mean age 58.1 years; BMI 28.6?kg/m2 ) and 1065 women (mean age 57.3 years; BMI 27.2?kg/m2 ). We used sex-specific generalized estimating equations in multivariable regressions to estimate the difference (?) of annualized BMD change in percent (%?BMD) at each skeletal site per 5?g/d increase in dietary fiber. We further estimated the adjusted mean for bone loss (annualized %?BMD) among participants in each higher quartile (Q2, Q3, or Q4) compared with those in the lowest quartile (Q1) of fiber intake. Higher dietary total fiber (??=?0.06, p?=?0.003) and fruit fiber (??=?0.10, p?=?0.008) was protective against bone loss at the femoral neck in men but not in women. When examined in quartiles, men in Q2-Q4 of total fiber had significantly less bone loss at the femoral neck versus those in Q1 (all p?

SUBMITTER: Dai Z

PROVIDER: S-EPMC5990003 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Publications

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

Dai Zhaoli Z Zhang Yuqing Y Lu Na N Felson David T DT Kiel Douglas P DP Sahni Shivani S

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20171107 2

Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between sexes. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts, and legumes) and bone loss at the femoral neck, trochanter, and lumbar spine (L<sub>2</sub> to L<sub>4</sub> ) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed ...[more]

PMID: 29024045

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Project description:BackgroundDietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA).ObjectivesWe quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA.MethodsWe used longitudinal data from the Osteoarthritis Initiative (OAI) and the Framingham Offspring Osteoarthritis Study. At baseline of each study, men and women (mean age: 61 y) with or at risk of knee osteoarthritis were followed for 48 mo in the OAI. Adults (mean age: 53 y) were followed for 9.5 y in the Framingham study. Dietary fiber intake was estimated using a validated food-frequency questionnaire. Measured weight and height were used to calculate BMI. Serum high-sensitivity C-reactive protein (CRP) was measured in the Framingham study only. Incident SXKOA was defined as new onset of a combination of knee pain and radiographic osteoarthritis. We applied marginal structural models to quantify the mediation through BMI in the OAI and the sequential mediation through BMI and CRP in the Framingham study.ResultsIncident SXKOA occurred in 861 knees among 2876 persons in the OAI and in 143 knees among 971 persons in the Framingham study. In persons whose fiber intake was ≥21 g/d compared with those with intakes <21 g/d, the OR (95% CI) was 0.70 (0.53, 0.91) for the overall association with SXKOA and was 0.93 (0.92, 0.95) for the mediation via BMI (per kg/m2) in the OAI. In the Framingham study, the overall association was 0.57 (0.30, 1.09), the mediation through BMI (via BMI and the influence of BMI on CRP) was 0.94 (0.85, 1.02), and the mediation through CRP (per milligram per liter) was 0.99 (0.84, 1.19).ConclusionOur findings suggest that the inverse association of fiber intake and the risk of incident symptomatic knee osteoarthritis is partially mediated by BMI.

Dataset Information

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

Publications

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

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