Ontology highlight
ABSTRACT:
SUBMITTER: Chapman LM
PROVIDER: S-EPMC5990278 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20180518 11
(+)-Psiguadial B is a diformyl phloroglucinol meroterpenoid that exhibits antiproliferative activity against the HepG2 human hepatoma cancer cell line. This full account details the evolution of a strategy that culminated in the first enantioselective total synthesis of (+)-psiguadial B. A key feature of the synthesis is the construction of the trans-cyclobutane motif by a Wolff rearrangement with in situ catalytic, asymmetric trapping of the ketene. An investigation of the substrate scope of th ...[more]