Dataset Information

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.

ABSTRACT: In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p?

SUBMITTER: Stauder R

PROVIDER: S-EPMC5990524 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.

Stauder Reinhard R Yu Ge G Koinig Karin A KA Bagguley Tim T Fenaux Pierre P Symeonidis Argiris A Sanz Guillermo G Cermak Jaroslav J Mittelman Moshe M Hellström-Lindberg Eva E Langemeijer Saskia S Holm Mette Skov MS Mądry Krzysztof K Malcovati Luca L Tatic Aurelia A Germing Ulrich U Savic Aleksandar A van Marrewijk Corine C Guerci-Bresler Agnès A Luño Elisa E Droste Jackie J Efficace Fabio F Smith Alex A Bowen David D de Witte Theo T

Leukemia 20180306 6

In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients r ...[more]

PMID: 29572506

Dataset Information

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.

Publications

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study.

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