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Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates.

ABSTRACT: A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance.

SUBMITTER: Luo X

PROVIDER: S-EPMC5990840 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates.

Luo Xiaojun X Liu Qiang Q Zhu Hongxia H Chen Huoji H

Royal Society open science 20180530 5

A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance. ...[more]

PMID: 29892452

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