Ontology highlight
ABSTRACT:
SUBMITTER: Lei J
PROVIDER: S-EPMC5991201 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lei Jinzhi J Nie Qing Q Chen Dong-Bao DB
Biology of reproduction 20180601 6
Experimental evidence shows that parental psychological stress affects the long-term health of offspring in an inheritable fashion. Although epigenetic mechanisms, including DNA methylation, miRNA, and histone modifications, are involved in transgenerational programming, the underlining mechanisms of transgenerational inheritance remain unsolved. Here, we present a single-cell-based computational model for transgenerational inheritance for investigating the long-term dynamics of phenotype change ...[more]