Transcriptomic Analysis of CD4⁺ T Cells Reveals Novel Immune Signatures of Latent Tuberculosis.

ABSTRACT: In the context of infectious diseases, cell population transcriptomics are useful to gain mechanistic insight into protective immune responses, which is not possible using traditional whole-blood approaches. In this study, we applied a cell population transcriptomics strategy to sorted memory CD4 T cells to define novel immune signatures of latent tuberculosis infection (LTBI) and gain insight into the phenotype of tuberculosis (TB)-specific CD4 T cells. We found a 74-gene signature that could discriminate between memory CD4 T cells from healthy latently Mycobacterium tuberculosis-infected subjects and noninfected controls. The gene signature presented a significant overlap with the gene signature of the Th1* (CCR6⁺CXCR3⁺CCR4^-) subset of CD4 T cells,

SUBMITTER: Burel JG 

PROVIDER: S-EPMC5991485 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature