The behavioral study on the interactive aggravation between pruritus and depression.

ABSTRACT:

Background

The interactive aggravation of pruritus and depression is well-known, but an appropriate experimental model that could mimic this behavioral phenomenon is still lacking. Thus, a systematic animal behavioral investigation was carried out in this study. This will promote the research and treatment of pruritus and depression.

Methods

The 2,4-dinitrofluorobenzene (DNFB)-induced chronic itch model was established to measure the depression index by forced swimming test (FST), tail suspension test (TST), and splash test (ST). The chronic unpredicted mild stress (CUMS)-induced depression model was established to measure spontaneous itch and acute histamine or chloroquine-induced itch behaviors. A depression and itch combining model was also established to measure the scra

SUBMITTER: Wang XD 

PROVIDER: S-EPMC5991569 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature