Ontology highlight
ABSTRACT:
SUBMITTER: Nowakowski TJ
PROVIDER: S-EPMC5991609 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nowakowski Tomasz J TJ Bhaduri Aparna A Pollen Alex A AA Alvarado Beatriz B Mostajo-Radji Mohammed A MA Di Lullo Elizabeth E Haeussler Maximilian M Sandoval-Espinosa Carmen C Liu Siyuan John SJ Velmeshev Dmitry D Velmeshev Dmitry D Ounadjela Johain Ryad JR Shuga Joe J Wang Xiaohui X Lim Daniel A DA West Jay A JA Leyrat Anne A AA Kent W James WJ Kriegstein Arnold R AR
Science (New York, N.Y.) 20171201 6368
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified discrete cell types as well as temporally and spatially restricted trajectories of radial glia maturation and neurogenesis in developing human telencephalon. These lineage-specific trajectories reveal the expression of neurogenic transcription factors in early r ...[more]