Unknown

Dataset Information

0

Treatment patterns and outcomes in patients with metastatic gastric cancer receiving third-line chemotherapy: A population-based outcomes study.


ABSTRACT:

Purpose

There is limited data on third-line chemotherapy in patients with metastatic gastric cancer (MGC). This study was conducted to assess third-line treatment patterns, outcomes, and clinical parameters related to survival outcomes in patients with MGC.

Methods

Using the Korean Health Insurance Review and Assessment Service (HIRA) database, a nationwide population-based outcomes study was conducted. From the HIRA database, patients newly diagnosed in 2010 with MGC were identified (N = 1,871), and of these, 229 patients who had received third-line chemotherapy were finally selected for this study.

Results

Prior to third-line chemotherapy, more than 90% of patients received fluoropyrimidine and platinum, and 43.7% and 40.6% received taxane and irinotecan, respectively. Various third-line chemotherapy regimens containing taxane (docetaxel or paclitaxel), irinotecan, or oxaliplatin were prescribed. The median overall survival (OS) of all patients receiving third-line chemotherapy was 4.4 months. The median time from the start date of first-line chemotherapy to the start date of third-line chemotherapy (TF1T3) was 9.5 months, and a longer TF1T3 was the only factor that was significantly associated with an increased OS. The median OS of patients who had received fluoropyrimidine, platinum, and taxane followed by third-line irinotecan-based therapy was similar to that of patients who had received fluoropyrimidine, platinum, and irinotecan followed by third-line taxane-based therapy (p = 0.894).

Conclusion

In patients with MGC receiving third-line chemotherapy, TF1T3 was the only significant factor associated with OS. The sequence of using taxane and irinotecan as subsequent therapy after first-line failure was not shown to impact survival outcome.

SUBMITTER: Choi IS 

PROVIDER: S-EPMC5991719 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

Treatment patterns and outcomes in patients with metastatic gastric cancer receiving third-line chemotherapy: A population-based outcomes study.

Choi In Sil IS   Choi Mihong M   Lee Ju Hyun JH   Kim Jee Hyun JH   Suh Koung Jin KJ   Lee Ji Yun JY   Kang Beodeul B   Kim Ji-Won JW   Kim Se-Hyun SH   Kim Jin Won JW   Lee Jeong-Ok JO   Kim Yu Jung YJ   Bang Soo-Mee SM   Lee Jong Seok JS   Lee Keun-Wook KW  

PloS one 20180607 6


<h4>Purpose</h4>There is limited data on third-line chemotherapy in patients with metastatic gastric cancer (MGC). This study was conducted to assess third-line treatment patterns, outcomes, and clinical parameters related to survival outcomes in patients with MGC.<h4>Methods</h4>Using the Korean Health Insurance Review and Assessment Service (HIRA) database, a nationwide population-based outcomes study was conducted. From the HIRA database, patients newly diagnosed in 2010 with MGC were identif  ...[more]

Similar Datasets

| S-EPMC6197657 | biostudies-literature
| S-EPMC7201990 | biostudies-literature
| S-EPMC6600493 | biostudies-literature
| S-EPMC7467430 | biostudies-literature
| S-EPMC7191061 | biostudies-literature
| S-EPMC5478304 | biostudies-literature
| S-EPMC9633934 | biostudies-literature
| S-EPMC7352495 | biostudies-literature
| S-EPMC9618512 | biostudies-literature