Ontology highlight
ABSTRACT:
SUBMITTER: Adeyemo TA
PROVIDER: S-EPMC5991720 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Adeyemo Titilope A TA Ojewunmi Oyesola O OO Oyetunji Idat A IA Rooks Helen H Rees David C DC Akinsulie Adebola O AO Akanmu Alani S AS Thein Swee Lay SL Menzel Stephan S
PloS one 20180607 6
Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia (SCA). We carried out the first systematic evaluation of critical single nucleotide polymorphisms at these disease modifier loci in Nigerian patients with SCA. Common variants for BCL11A and HBS1L-MYB were strongly associated with HbF levels. At both ...[more]