Ontology highlight
ABSTRACT:
SUBMITTER: Fisher KJ
PROVIDER: S-EPMC5991770 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Fisher Kaitlin J KJ Buskirk Sean W SW Vignogna Ryan C RC Marad Daniel A DA Lang Gregory I GI
PLoS genetics 20180525 5
Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly experience whole-genome duplication (WGD). We report recurrent genome duplication in 46 haploid yeast populations evolved for 4,000 generations. We find that WGD confers a fitness advantage, and this immediate fitness gain is accompanied by a shift in ge ...[more]