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Trends and spatial patterns of mortality related to neglected tropical diseases in Brazil.


ABSTRACT: We analysed nationwide trends and spatial distribution of NTD-related mortality in Brazil. We included all death certificates in Brazil from 2000 to 2011, in which NTDs were recorded as any causes of death. A total of 100,814/12,491,280 (0.81%) death certificates were identified, which mentioned at least one NTD. Age-adjusted NTD-related mortality rates showed a significant decrease over time (annual percent change [APC]: - 2.1%; 95% CI: - 2.8 to - 1.3), with decreasing mortality rates in the Southeast, South, and Central-West regions, stability in the Northeast region, and increase in the North region. We identified spatial and spatiotemporal high-risk clusters for NTD-related mortality in all regions, with a major cluster covering a wide geographic range in central Brazil. Despite nationwide decrease of NTD-related mortality in the observation period, regional differences remain, with increasing mortality trends especially in the socioeconomically disadvantaged regions of the country. The existence of clearly defined high-risk areas for NTD-related deaths reinforces the need for integrated prevention and control measures in areas with highest disease burden.

SUBMITTER: Martins-Melo FR 

PROVIDER: S-EPMC5991825 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Trends and spatial patterns of mortality related to neglected tropical diseases in Brazil.

Martins-Melo Francisco Rogerlândio FR   Ramos Alberto Novaes AN   Alencar Carlos Henrique CH   Heukelbach Jorg J  

Parasite epidemiology and control 20160407 2


We analysed nationwide trends and spatial distribution of NTD-related mortality in Brazil. We included all death certificates in Brazil from 2000 to 2011, in which NTDs were recorded as any causes of death. A total of 100,814/12,491,280 (0.81%) death certificates were identified, which mentioned at least one NTD. Age-adjusted NTD-related mortality rates showed a significant decrease over time (annual percent change [APC]: - 2.1%; 95% CI: - 2.8 to - 1.3), with decreasing mortality rates in the So  ...[more]

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