Ontology highlight
ABSTRACT:
SUBMITTER: Blum LK
PROVIDER: S-EPMC5992033 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Blum Lisa K LK Cao Richard R L RRL Sweatt Andrew J AJ Bill Matthew M Lahey Lauren J LJ Hsi Andrew C AC Lee Casey S CS Kongpachith Sarah S Ju Chia-Hsin CH Mao Rong R Wong Heidi H HH Nicolls Mark R MR Zamanian Roham T RT Robinson William H WH
European journal of immunology 20180222 5
Idiopathic pulmonary arterial hypertension (IPAH) is a devastating pulmonary vascular disease in which autoimmune and inflammatory phenomena are implicated. B cells and autoantibodies have been associated with IPAH and identified as potential therapeutic targets. However, the specific populations of B cells involved and their roles in disease pathogenesis are not clearly defined. We aimed to assess the levels of activated B cells (plasmablasts) in IPAH, and to characterize recombinant antibodies ...[more]