Identification of preoperative factors associated with outcomes following surgical management of intra-abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy.
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ABSTRACT:
SUBMITTER: Roland CL
PROVIDER: S-EPMC5992050 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Identification of preoperative factors associated with outcomes following surgical management of intra-abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy.
Roland Christina L CL Bednarski Brian K BK Watson Kelsey K Torres Keila E KE Cormier Janice N JN Wang Wei-Lien WL Lazar Alexander J AJ Somaiah Neeta N Hunt Kelly K KK Feig Barry W BW
Journal of surgical oncology 20180215 5
<h4>Background</h4>The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy.<h4>Methods</h4>We identified 107 patients with metastatic or recurrent GIST treated with TKIs and surgical resection (2002-2012). Patients that underwent palliative or incom ...[more]
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