Ontology highlight
ABSTRACT:
SUBMITTER: Lei FX
PROVIDER: S-EPMC5992182 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lei Fu Xi FX Jin Lei L Liu Xiao Ying XY Lai Fritz F Yan Xu Guang XG Farrelly Margaret M Guo Su Tang ST Zhao Xin Han XH Zhang Xu Dong XD
Cell death & disease 20180607 6
Many recent studies have uncovered the necessary role for the receptor-interacting protein kinase 1 (RIP1) in regulating apoptosis and necrosis that cells undergo in response to various cellular stresses. However, the functional significance of RIP1 in promoting cancer cells survival remains poorly understood. Here, we report that RIP1 was upregulated and contributed to both intrinsic and acquired resistance of melanoma cells to BRAF/MEK inhibitors through activation of NF-κB. Strikingly, Snail1 ...[more]