Expression Differentiation Is Not Helpful in Identifying Prognostic Genes Based on TCGA Datasets.

ABSTRACT: A routine pipeline seems very common in many cancer studies that expression differentiation might be helpful in identifying prognostic molecules. There also exists a striking unanimity that molecules upregulated in cancer usually shorten survival, while downregulated ones have the opposite effect. In this study, based on the transcriptional profiles of 18 malignancies, cancer and corresponding adjacent normal tissues were used to calculate differential scores. Cox correlation coefficients of global genes were also calculated to denote survival association. The relationship between expression differentiation and survival association has been extensively studied in 18 malignancy types. Contradictory to our stereotypic research pattern, expression differentiation between cancer and adjacent n

SUBMITTER: An N 

PROVIDER: S-EPMC5992444 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature