Ontology highlight
ABSTRACT:
SUBMITTER: Callegari E
PROVIDER: S-EPMC5992479 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Callegari Elisa E D'Abundo Lucilla L Guerriero Paola P Simioni Carolina C Elamin Bahaeldin K BK Russo Marta M Cani Alice A Bassi Cristian C Zagatti Barbara B Giacomelli Luciano L Blandamura Stella S Moshiri Farzaneh F Ultimo Simona S Frassoldati Antonio A Altavilla Giuseppe G Gramantieri Laura L Neri Luca Maria LM Sabbioni Silvia S Negrini Massimo M
Molecular therapy. Nucleic acids 20180412
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Prognosis is poor, and therapeutic options are limited. MicroRNAs (miRNAs) have emerged as potential therapeutic molecules against cancer. Here, we investigated the therapeutic efficacy of miR-199a-3p, an miRNA highly expressed in normal liver and downregulated in virtually all HCCs. The therapeutic value of miR-199a-3p mimic molecules was assayed in the TG221 mouse, a transgenic model highly predispose ...[more]