Ontology highlight
ABSTRACT:
SUBMITTER: Abbink P
PROVIDER: S-EPMC5992501 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Abbink Peter P Larocca Rafael A RA Dejnirattisai Wanwisa W Peterson Rebecca R Nkolola Joseph P JP Borducchi Erica N EN Supasa Piyada P Mongkolsapaya Juthathip J Screaton Gavin R GR Barouch Dan H DH
Nature medicine 20180604 6
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV. ...[more]